General
Preferred name
NVS-CECR2-1
Synonyms
NVS-1 ()
P&D ID
PD000029
CAS
1992047-61-6
Tags
available
probe
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
3
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC50=47 nM; KD=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism[1].
PRICE
165
DESCRIPTION
NVS-CECR2-1 is a selective cat eye syndrome chromosome region candidate 2 (CECR2) inhibitor with antitumor activity and inhibits chromatin binding of CECR2 BRD. NVS-CECR2-1 is cytotoxic and can induce apoptosis.
DESCRIPTION
NVS-1 is a small-molecule selective inhibitor of the bromodomain-containing protein cat eye syndrome chromosome region, candidate 2 (CECR2) . NVS-1 is one of the compounds available from the Structural Genomics Consortium's epigenetic probes set. It was developed in collaboration with Novartis.
(GtoPdb)
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC50 = 47 nM). NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. CECR2 (cat eye syndrome chromosome region, candidate 2) is a component of chromatin complexes that regulate gene expression controlling development.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Gene switch ligand for use in inducible gene expression systems
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Bromodomains chemical toolbox
Cayman Chemical Bioactives
Chemical Probes.org
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
SGC Probes
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
10
Molecular Weight
495.27
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
5.34
TPSA
88.91
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Bromodomains
MOA
Inhibitor
CECR2 inhibitor
CECR2 inhbitor
Member status
member
Pathway
Apoptosis
Epigenetics
Solubility
DMSO to 100 mM
Target
CECR2
Epigenetic Reader Domain
Target class
Epigenetic
Target subclass
Bromodomain
Control
NVS-CECR2-C
Source data
